| 氏名 |
坂元 尚哉（サカモト ナオヤ / SAKAMOTO Naoya）
|
|---|---|
| 職位 | 准教授 |
| 所属 | 機械システム工学科 機械システム工学域
2017年度以前の所属
知能機械システムコース 知能機械システム学域 |
| 年報 | 202120192018201720162015 |
研究紹介
細胞培養作業の様子と線維芽細胞の蛍光顕微鏡画像
生物学的な手法に力学的観点や工学的技術を組み合わせ、新たな生体機能・構造制御メカニズム解明を目指しています。
| 専門・研究分野 | メカノバイオロジー，バイオメカニクス，生体医工学 |
|---|---|
| 最終学歴・学位 | 博士（工学） |
| 研究テーマ | 力学環境に対する細胞応答，細胞の力学応答メカニズム，血管疾患，細胞核メカノバイオロジー |
| 研究キーワード | メカノバイオロジ－，細胞バイオメカニクス，生体医工学 |
| 研究業績・著書・論文、その他それに準じる業績 | ・N. Sakamoto, K. Ito, S. Ii, D.E. Conway, Y. Ueda, J. Nagatomi: A homeostatic role of nucleus-actin filament coupling in the regulation of cellular traction forces in fibroblasts. Biomechanics and Modeling in Mechanobiology, 2024. (https://doi.org/10.1007/s10237-024-01839-1) ・坂元 尚哉, 上野 竜汰, 大八木 貴史, 武居 直行：接着基質伸展に伴う細胞核動的変形挙動解析に向けたその場観察装置の開発．日本機械学会論文集，90巻，930号，p23-00299，2024．（https://doi.org/10.1299/transjsme.23-00299） ・K. Sawasaki, M. Nakamura, S. Imada, Y. Horie, K. Takahashi, R. Yamazaki, N. Kimura, K. Kawahito, N. Sakamoto: Disruptive Effect of Impinging Jet Flow Environment on the Integrity of Endothelial Monolayer. Journal of Biorheology, Vol. 37 (2), pp. 130-137, 2023. (https://doi.org/10.17106/jbr.37.130) ・Y. Ueda, N. Sakamoto: A Combined Application of Cyclic Stretching and Spheroid Culture Promotes Endothelial Differentiation of Mesenchymal Stem Cells. Journal of Biorheology, Vol. 37 (2), pp. 88-95, 2023 (https://doi.org/10.17106/jbr.37.88). ・T. Miyano, A. Suzuki, N. Sakamoto: Actin cytoskeletal reorganization is involved in hyperosmotic stress-induced autophagy in tubular epithelial cells. Biochemical and Biophysical Research Communications, Vol. 663, pp. 1-7, 2023. (https://doi.org/10.1016/j.bbrc.2023.04.070) ・坂元 尚哉, 舘林 耕平, 三好 洋美：壁せん断応力―引張ひずみ組合せ刺激が間葉系幹細胞の内皮分化に及ぼす影響．日本機械学会論文集，88巻，911号，p. 22-00103，2022．（https://doi.org/10.1299/transjsme.22-00103）2022/7/25 ・T. Miyano, A. Suzuki, N. Sakamoto: Calcium influx through TRPV4 channels involve in hyperosmotic stress-induced epithelial-mesenchymal transition in tubular epithelial cells. Biochemical and Biophysical Research Communications, Vol. 617, pp. 48-54, 2022. (https://doi.org/10.1016/j.bbrc.2022.06.003) ・Y. Hiroshima, Y. Oyama, K. Sawasaki, M. Nakamura, N. Kimura, K. Kawahito, H. Fujie, N. Sakamoto: A Compressed Collagen Construct for Studying Endothelial–Smooth Muscle Cell Interaction under High Shear Stress. Annals of Biomedical Engineering, Vol. 50, pp. 951-963, 2022. (https://doi.org/10.1007/s10439-022-02972-7) ・Xu Y, Sakamoto N, Kotake Y, Yamasaki M, Numao M, Fujie H: Microscopic observation of centrifugally compressed cell-collagen combined constructs (C6) developed for soft tissue repair. 臨床バイオメカニクス． ・S. Tsukamoto, K.-H, Chiam, T. Asakawa, K. Sawasaki, N. Takesue, N. Sakamoto: Compressive forces driven by lateral actin fibers are a key to the nuclear deformation under uniaxial cell-substrate stretching. Biochemical and Biophysical Research Communications, Vol. 597, pp. 37-43, 2022 (https://doi.org/10.1016/j.bbrc.2022.01.107). ・T. Miyano, A. Suzuki, N. Sakamoto: Hyperosmotic stress induces epithelial-mesenchymal transition through rearrangements of focal adhesions in tubular epithelial cells. PLOS ONE, Vol 16, No. 12, e0261345, 2021. (https://doi.org/10.1371/journal.pone.0261345) ・K. Matsushita, C. Nakahara, S. Kimura, N. Sakamoto, S. Ii, H. Miyoshi: Intranuclear mesoscale viscoelastic changes during osteoblastic differentiation of human mesenchymal stem cells. FASEB Journal, Vol 35, No. 12, e22071, 2021 ・S. Tsukamoto, T. Asakawa, S. Kimura, N. Takesue, M.R.K. Mofrad, N. Sakamoto: Intranuclear strain in living cells subjected to substrate stretching: A combined experimental and computational study. Journal of Biomechanics, Vol. 119, 2021. (10.1016/j.jbiomech.2021.110292) ・J. Pauty, S. Nakano, R. Usuba, T. Nakajima, Y. Johmura, S. Omori, N. Sakamoto, A. Kikuchi, M. Nakanishi, Y. T. Matsunaga: A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels, Biomaterials Science, Vol. 9, pp. 199-211, 2021. (10.1039/D0BM01297A) ・X. Han, N. Sakamoto, N. Tomita, H. Meng, M. Sato, M. Ohta: Influence of TGF-β1 expression in endothelial cells on smooth muscle cell phenotypes and MMP prodution under shear stress in a co-culture model, Cytotechnology, Vol. 71 (2), pp. 489-496, 2019. (10.1007/s10616-018-0268-7) ・N. Sakamoto, Y. Ueki, M. Oi, T. Kiuchi, M. Sato: Fluid shear stress suppresses ICAM-1-mediated transendothelial migration of leukocytes in coculture model, Biochemical and Biophysical Research Communications, Vol. 502 (3), pp. 403-408, 2018. (10.1016/j.bbrc.2018.05.182) ・D. Yoshino, N. Sakamoto, M. Sato: Fluid shear stress combined with shear stress spatial gradients regulate vascular endothelial morphology, Integrative Biology, Vol. 9 (7), pp. 584-594, 2017. (10.1039/C7IB00065K) ・N. Sakamoto, M. Ogawa, K. Sadamoto, M. Takeuchi, N. Kataoka: Mechanical role of nesprin-1-mediated nucleus-actin filament binding in cyclic stretch-induced fibroblast elongation. Cellular and Molecular Bioengineering, Vol. 10 (4), pp. 327-338, 2017. (10.1007/s12195-017-0487-6) ・X. Han, N. Sakamoto, N. Tomita, H. Meng, M. Sato, M. Ohta: Influence of shear stress on phenotype and MMP production of smooth muscle cells in a co-culture model. Journal of Biorheology, Vol. 31 (2), pp. 50-56, 2017. (10.17106/jbr.31.50) ・N. Sakamoto, K. Sadamoto: Effect of low oxygen conditions on matrix metalloproteinase-9 production of macrophages subjected to cyclic stretching: involvement of ERK and Rho kinase pathways. Journal of Biomechanical Science and Engineering, Vol. 12 (1), p. 16-00590, 2017. (10.1299/jbse.16-00590) |
| 受 賞 | ― |
| 主な学会活動 | 日本機械学会 日本生体医工学会 日本バイオレオロジー学会 米国生体医工学会（Biomedical Engineering Society） |
| 社会等との関わり | ― |
| 個人のURL | ― |
| 担当科目 |
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| オフィスアワー | ― |
| 研究室 | 南大沢キャンパス 生体機械工学研究棟10号館204室 南大沢キャンパス 生体機械工学研究棟10号館213室 日野キャンパス 1号館253室 |
| 内線番号 | 4664 |
| メールアドレス |
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| 研究室サイト等 | http://www.comp.sd.tmu.ac.jp/mechanobio/ |